期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 35, 页码 31615-31626出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b09296
关键词
phototherapy; plasmon-induced resonance energy transfer; Prussian blue; magnetic resonance imaging; photoacoustic imaging; biocompatibility
资金
- Villum Fonden, Denmark [13153]
- China Scholarship Council (CSC)
Phototherapy, including photothermal and photodynamic therapy, has attracted extensive attention due to its noninvasive nature, low toxicity, and high anticancer efficiency. The charge-separation mechanism of plasmon-induced resonance energy transfer (PIRET) has been increasingly employed to design nanotheranotic agents. Herein, we developed a novel and smart PIRET-mediated nanoplatform for enhanced, imaging-guided phototherapy. Prussian blue (PB) was incorporated into a Au@Cu2O nanostructure, which was then assembled with poly(allylamine) (PAH)-modified black phosphorus quantum dots (Au@PB@Cu2O@BPQDs/PAH nanocomposites). The hybrid nanosystem exhibited great absorption in the near-infrared region, as well as the ability to self-supply O-2 by catalyzing hydrogen peroxide and convert O-2 into singlet oxygen (O-1(2)) under 650 nm laser light (0.5 W/cm(2)) irradiation. In vitro and in vivo assays showed that the generated heat and toxic O-1(2) from Au@PB@Cu2O@BPQDs/PAH nanocomposites could effectively kill the cancer cells and suppress tumor growth. Moreover, the unique properties of the PB-modified nanosystem allowed for synergistic therapy with the aid of T-1-weighed magnetic resonance imaging (T-1-weighted magnetic resonance imaging) and photoacoustic imaging. This study presented a suitable way to fabricate smart PIRET-based nanosystems with enhanced photothermal therapy/photodynamic therapy efficacy and dual-modality imaging functionality. The great biocompatibility and low toxicity ensured their high potential for use in cancer therapy.
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