期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 31, 页码 27521-27528出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b06170
关键词
InSe; two-dimensional nanomaterials; NIR-II; drug release; cancer treatment
资金
- National Natural Science Foundation of China [81501577]
- Leading Talents of Guangdong Province Program [00201520]
- Shenzhen Peacock Program [KQTD2016030111500545]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [CityU 1120561]
Near-infrared-II (NIR-II) biowindow is appealing from the perspectives of larger maximum permissible exposure in comparison with the nearinfrared-I biowindow, so the NIR-II-responsive drug-delivery nanoplatform is highly desirable. In this work, two-dimensional InSe nanosheets (InSe NSs) are modified with poly(ethylene glycol) and evaluated as an effective NIR-II-responsive cancer treatment nanoplatform. The InSe NSs synthesized by liquid exfoliation exhibit prominent NIR-II-responsive photothermal conversion efficiency (39.5%) and photothermal stability. Moreover, the InSe NSs have a doxorubicin (DOX) loading capacity as high as 93.6%, along with excellent NIR-II-responsive DOX release characteristic. The superior synergistic chemo/photothermal effects have also been demonstrated by the in vitro experiments in killing cancer cells. In combination with good biocompatibility, the InSe NSs have great potential in therapeutic applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据