期刊
NATURE BIOMEDICAL ENGINEERING
卷 3, 期 8, 页码 632-643出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41551-019-0380-9
关键词
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资金
- National Natural Science Foundation of China [81622032, 51672184, 31571527, 81501858]
- National Science Foundation [CMMI-1562904]
- Jiangsu Innovation and Entrepreneurship Program
- National Key RAMP
- D Program of China [2016YFC1000500, 2016YFC1305100, 2014CB748600]
- Science and Technology Commission of Shanghai Municipality [17XD1400300, 17JC1400200]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Acellular epicardial patches that treat myocardial infarction by increasing the mechanical integrity of damaged left ventricular tissues exhibit widely scattered therapeutic efficacy. Here, we introduce a viscoelastic adhesive patch, made of an ionically crosslinked transparent hydrogel, that accommodates the cyclic deformation of the myocardium and outperforms most existing acellular epicardial patches in reversing left ventricular remodelling and restoring heart function after both acute and subacute myocardial infarction in rats. The superior performance of the patch results from its relatively low dynamic modulus, designed at the so-called 'gel point' via finite-element simulations of left ventricular remodelling so as to balance the fluid and solid properties of the material.
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