期刊
NATURE BIOMEDICAL ENGINEERING
卷 3, 期 5, 页码 339-353出版社
NATURE PORTFOLIO
DOI: 10.1038/s41551-019-0392-5
关键词
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资金
- CRUK [C14303/A17197, C47594/A16267, C47594/A21102, C55962/A24669]
- EPSRC [C197/A16465, EP/N014588/1]
- EPSRC [EP/N014588/1, EP/R003599/1] Funding Source: UKRI
Clinical workflows for the non-invasive detection and characterization of disease states could benefit from optical-imaging biomarkers. In this Perspective, we discuss opportunities and challenges towards the clinical implementation of optical-imaging biomarkers for the early detection of cancer by analysing two case studies: the assessment of skin lesions in primary care, and the surveillance of patients with Barrett's oesophagus in specialist care. We stress the importance of technical and biological validations and clinical-utility assessments, and the need to address implementation bottlenecks. In addition, we define a translational roadmap for the widespread clinical implementation of optical-imaging technologies.
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