期刊
BIOMATERIALS
卷 69, 期 -, 页码 45-55出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2015.08.009
关键词
Collagen; Vascular endothelial growth factors; Urethral regeneration; Collagen-binding domain
资金
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01030000]
- Chongqing Science & Technology Commission [cstc2013kjrc ljrccj 10001, cstc2013kjrc-qnrc10008]
Extensive urethral defects have a serious impact on quality of life, and treatment is challenging. A shortage of material for reconstruction is a key limitation. Improving the properties of biomaterials and making them suitable for urethral reconstruction will be helpful. Previously, we constructed a fusion protein, collagen-binding VEGF (CBD-VEGF), which can bind to collagen scaffold, stimulate cell proliferation, and promote angiogenesis and tissue regeneration. We proposed that CBD-VEGF could improve the performance of collagen in reconstruction of extensive urethral defects. Our results showed that collagen scaffolds modified with CBD-VEGF could promote urethral tissue regeneration and improve the function of the neo-urethra in a beagle extensive urethral defect model. Thus, modifying biomaterials with bioactive factors provides an alternative strategy for the production of suitable biomaterials for urethral reconstruction. (C) 2015 Elsevier Ltd. All rights reserved.
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