期刊
PHARMACEUTICS
卷 11, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics11050242
关键词
cancer targeted therapy; drug delivery; black phosphorus; quantum dots; photothermal therapy
资金
- National Natural Science Foundation of China [81772449, 81771966, 51703258]
- Guangzhou Science, Technology and Innovation Commission [201804010309, 201803010090]
- Science, Technology and Innovation Commission of Shenzhen Municipality [JCYJ20160531195129079, JCYJ20170811160129498, JCYJ20180307154606793]
Due to the inherent limitations, single chemo or photothermal therapies (PTT) are always inefficient. The combination of chemotherapy and PTT for the treatment of cancers has attracted a great interest during the past few years. As a photothermal agent, black phosphorus quantum dots (BPQDs) possess an excellent extinction coefficient, high photothermal conversion efficacy, and good biocompatibility. Herein, we developed a photo- and pH-sensitive nanoparticle based on BPQDs for targeted chemo-photothermal therapy. Doxorubicin (DOX) was employed as a model drug. This nanosystem displayed outstanding photothermal performance both in vitro and in vivo. Folic acid conjugation onto the surface endowed this system an excellent tumor-targeting effect, which was demonstrated by the cellular targeting assay. The BPQDs-based drug delivery system exhibited pH- and photo-responsive release properties, which could reduce the potential damage to normal cells. The in vitro cell viability study showed a synergistic effect in suppressing cancer cell proliferation. Therefore, this BPQDs-based drug delivery system has substantial potential for future clinical applications.
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