期刊
CELLS
卷 8, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/cells8050407
关键词
Hippo pathway; cancer; angiogenesis; vascular mimicry; YAP; TAZ; MST1; 2; LATS1; 2
类别
资金
- Canadian Institute of Health Research (CIHR) [119325, 148629]
- Canadian Cancer Society (CRS)/Canadian Breast Cancer Foundation (CBCF)
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a physiological process that begins in utero and continues throughout life in both good health and disease. Understanding the underlying mechanism in angiogenesis could uncover a new therapeutic approach in pathological angiogenesis. Since its discovery, the Hippo signaling pathway has emerged as a key player in controlling organ size and tissue homeostasis. Recently, new studies have discovered that Hippo and two of its main effectors, Yes-associated protein (YAP) and its paralog transcription activator with PDZ binding motif (TAZ), play critical roles during angiogenesis. In this review, we summarize the mechanisms by which YAP/TAZ regulate endothelial cell shape, behavior, and function in angiogenesis. We further discuss how YAP/TAZ function as part of developmental and pathological angiogenesis. Finally, we review the role of YAP/TAZ in tumor vascular mimicry and propose directions for future work.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据