期刊
CANCERS
卷 11, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/cancers11050619
关键词
cancer-associated fibroblast; cancer metabolism; tumor-stroma crosstalk
类别
资金
- OHSU Fellowship for Diversity in Research
- NIH [R00 CA188259, R01 CA229580]
- American Cancer Society [132898-RSG-18-142-01-CSM]
- V Foundation V Scholar Award
- DOD Peer Reviewed Cancer Research Program Career Development Award [W81XWH-18-1-0437]
- Hirshberg Foundation Seed Grant
- Medical Research Foundation New Investigator Grant
- OHSU Brenden-Colson Center Pilot Award
- OHSU Knight Cancer Institute
- OHSU Cancer Early Detection Advanced Research Pilot Award
Fibroblast activation is an accompanying feature of solid tumor progression, resembling a conserved host response to tissue damage. Cancer-associated fibroblasts (CAFs) comprise a heterogeneous and plastic population with increasingly appreciated roles in tumor growth, metastatic capacity, and response to therapy. Classical features of fibroblasts in a wound-healing response, including profound extracellular matrix production and cytokine release, are recapitulated in cancer. Emerging evidence suggests that fibroblastic cells in the microenvironments of solid tumors also critically modulate cellular metabolism in the neoplastic compartment through mechanisms including paracrine transfer of metabolites or non-cell-autonomous regulation of metabolic signaling pathways. These metabolic functions may represent common mechanisms by which fibroblasts stimulate growth of the regenerating epithelium during a wound-healing reaction, or may reflect unique co-evolution of cancer cells and surrounding stroma within the tumor microenvironment. Here we review the recent literature supporting an important role for CAFs in regulation of cancer cell metabolism, and relevant pathways that may serve as targets for therapeutic intervention.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据