期刊
CANCERS
卷 11, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/cancers11050640
关键词
nanoparticle; drug delivery; ligand; active targeting; tumor targeting; biodistribution
类别
资金
- National Research Foundation of Korea (NRF) - Korean Government (Ministry of Science, ICT, & Future Planning) [2016R1C1B3013951]
- National Research Foundation of Korea [2016R1C1B3013951] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Targeting nanoparticle (NP) carriers to sites of disease is critical for their successful use as drug delivery systems. Along with optimization of physicochemical properties, researchers have focused on surface modification of NPs with biological ligands. Such ligands can bind specific receptors on the surface of target cells. Furthermore, biological ligands can facilitate uptake of modified NPs, which is referred to as 'active targeting' of NPs. In this review, we discuss recent applications of biological ligands including proteins, polysaccharides, aptamers, peptides, and small molecules for NP-mediated drug delivery. We prioritized studies that have demonstrated targeting in animals over in vitro studies. We expect that this review will assist biomedical researchers working with NPs for drug delivery and imaging.
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