期刊
CANCERS
卷 11, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/cancers11050670
关键词
dendritic cells; tumour-associated dendritic cells; immunotherapy; DC-therapy; DC-vaccinations
类别
资金
- Research Foundation Flanders (FWO)
- Kom op tegen kanker
- Vrije Universiteit Brussel (VUB)
- FWO
- VUB
Recent advances in cancer immunotherapy have mainly focused on re-activating T-cell responses against cancer cells. However, both priming and activation of effector T-cell responses against cancer-specific antigens require cross-talk with dendritic cells (DCs), which are responsible for the capturing, processing and presentation of tumour-(neo)antigens to T cells. DCs consequently constitute an essential target in efforts to generate therapeutic immunity against cancer. This review will discuss recent research that is unlocking the cancer-fighting potential of tumour-infiltrating DCs. First, the complexity of DCs in the tumour microenvironment regarding the different subsets and the difficulty of translating mouse data into equivalent human data will be briefly touched upon. Mainly, possible solutions to problems currently faced in DC-based cancer treatments will be discussed, including their infiltration into tumours, activation strategies, and antigen delivery methods. In this way, we hope to put together a broad picture of potential synergistic therapies that could be implemented to harness the full capacity of tumour-infiltrating DCs to stimulate anti-tumour immune responses in patients.
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