期刊
JOURNAL FOR IMMUNOTHERAPY OF CANCER
卷 7, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s40425-019-0590-4
关键词
Malignant pleural effusion; Immunotherapy; Pleural infiltrating T cells (PIT); Tumor associated nmcrophages (TAM)
资金
- Thoracic Surgery Foundation for Research and Education STS Research Grant [7/2016-7/2018]
- Department of Defense [BC032981, BC044784, W81XWH-12-1-0415, BC132245_W81XWH-14-0258]
- National Cancer Institute [R21 CA191647]
- Glimmer of Hope Foundation
- David Downing Fund
Malignant pleural effusions (MPE) are a common terminal pathway for many cancers, with an estimated United States incidence of more than 150,000 cases per year. MPE is an aggressive disease with a uniformly fatal prognosis and a life expectancy of only 3 to 12 months. The development of an effective targeted therapy represents a pressing unmet need. This commentary focuses on how cellular and humoral components condition the pleural space as a tumor-promoting, wound-healing environment. Despite an abundance of potential antigen presenting and effector cells in the pleura, their physical isolation by the mesothelial barrier, the concentration of cytokines and chemokines driving the epithelial to mesenchymal transition (EMT) and M2 /Th-2 polarization, suppress tumorspecific immune effector responses. We argue that local immune repolarization must precede either immune checkpoint or cellular therapy to successfully eradicate pleural tumor. We further hypothesize that, because of its cellular content, a repolarized pleural space will provide an effective immune environment for generation of systemic anti-tumor response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据