期刊
SCIENCE ADVANCES
卷 5, 期 5, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aav3058
关键词
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资金
- Carnegie Corporation of New York
- Horizon 2020
- National Research Foundation [78912, 81578]
- Deutsche Forschungsgemeinschaft [LA 2746/2]
- BBSRC [BB/R015856/1, BB/M025292/1]
- BBSRC [BB/R015856/1, BB/L009986/1, BB/M025292/1, BB/S003800/1] Funding Source: UKRI
- MRC [MR/N023706/1, G1001390] Funding Source: UKRI
Maternal immune transfer is the most significant source of protection from early-life infection, but whether maternal transfer of immunity by nursing permanently alters offspring immunity is poorly understood. Here, we identify maternal immune imprinting of offspring nursed by mothers who had a pre-conception helminth infection. Nursing of pups by helminth-exposed mothers transferred protective cellular immunity to these offspring against helminth infection. Enhanced control of infection was not dependent on maternal antibody. Protection associated with systemic development of protective type 2 immunity in T helper 2 (T(H)2) impaired IL-4R alpha(-/-) off-spring. This maternally acquired immunity was maintained into maturity and required transfer (via nursing) to the offspring of maternally derived T(H)2-competent CD4 T cells. Our data therefore reveal that maternal exposure to a globally prevalent source of infection before pregnancy provides long-term nursing-acquired immune benefits to offspring mediated by maternally derived pathogen-experienced lymphocytes.
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