期刊
SCIENCE ADVANCES
卷 5, 期 4, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aav4803
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资金
- Swiss National Science Foundation (SNSF) [P2EZP2-152184]
- Branco Weiss Fellowship-Society in Science
- NIH Molecular Biophysics Training Grant
- NSF Graduate Research Fellowship Program
- Koch Institute Support Grant from National Cancer Institute [P30-CA14051]
- Swiss National Science Foundation (SNF) [P2EZP2_152184] Funding Source: Swiss National Science Foundation (SNF)
Nanoparticles (NPs) have emerged as an advantageous drug delivery platform for the treatment of various ailments including cancer and cardiovascular and inflammatory diseases. However, their efficacy in shuttling materials to diseased tissue is hampered by a number of physiological barriers. One hurdle is transport out of the blood vessels, compounded by difficulties in subsequent penetration into the target tissue. Here, we report the use of two distinct micropropellers powered by rotating magnetic fields to increase diffusion-limited NP transport by enhancing local fluid convection. In the first approach, we used a single synthetic magnetic microrobot called an artificial bacterial flagellum(ABF), and in the second approach, we used swarms of magnetotactic bacteria (MTB) to create a directable living ferrofluid by exploiting ferrohydrodynamics. Both approaches enhance NP transport in a microfluidic model of blood extravasation and tissue penetration that consists of microchannels bordered by a collagen matrix.
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