期刊
CHEMISTRYSELECT
卷 4, 期 17, 页码 5155-5159出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201901356
关键词
Antioxidant mechanism; Apigenin; Biosynthesis; Naringenin; Naringenin chalcone; Structure-activity
资金
- Guangdong Science and Technology Project [2017 A050506043]
- Guangdong Provincial Education Office Science and Technology Project [2017KCXTD007]
- National Nature Science Foundation of China [81573558]
Naringenin chalcone (NAC) can undergo biosynthesis to convert into dihydroflavonoid naringenin and then to flavonoid apigenin. To explore the antioxidant change during this biosynthesis, the three were comparatively analyzed using several methods. Ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry analysis gave a dimer MS peak and an adduct MS peak when each of them mixing the 1,1'-diphenyl-2-picrylhydrazyl radical. In antioxidant colorimetric analyses, the IC50 values increased in the order NAC < apigenin < naringenin. Thus, the three can scavenge free radicals via a chain reaction including propagation and termination steps. The propagation step involves a hydrogen-atom-abstraction (or electron-transfer plus H+-transfer) antioxidant mechanism. From NAC to naringenin, the antioxidant potential decreases, possibly due to enzymatic cyclization, which eliminates a phenolic -OH and saturates a C=C bond. From naringenin to apigenin, the antioxidant potential increases because the 2,3-dehydrogenation reaction cause extended - conjugation. In the termination step, each of them forms a dimer product and an adduct-with-radical product.
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