Biocompatible Tin Oxide Nanoparticles: Synthesis, Antibacterial, Anticandidal and Cytotoxic Activities

Biocompatible SnO2 NPs, were synthesized by simple and facile ultrasonic technique, and further studied for antibacterial, anticandidal and invitro cytotoxic activity. The obtained size of synthesized SnO2 NPs, was 5-30nm and characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The evaluation of antibacterial and anticandidal activity of the SnO2 NPs, was done by determining the minimum inhibitory concentration (MIC), and minimum bactericidal/fungicidal concentration (MBC/MFC), against Escherichia coli and Candida albicans, respectively. The MIC of 0.5mg/ml and MBC of >1mg/ml for E. coli, while as the MIC of 8mg/ml and MFC >16mg/ml for C. albicans, was obtained. Maximum activity for both, bacteria and Candida was achieved, however, to the best of our knowledge, this is the first report of anticandidal activity exhibited by SnO2 NPs. Treatment of synthesized SnO2 NPs against the colorectal (HCT-116) cancer cell line, decreased the cell survivability in a dose-dependent manner, as lower dose showed decrease of 73.00%, whereas, higher dosage caused a significant 31.34% decrease in the cell viability. The obtained results confirmed, that the prepared SnO2 NPs can be the future broad-spectrum antibacterial, anticandidal and anticancer agent, and can be further explored for application in the biomedical field.