4.3 Article

Androgen deprivation therapy promotes an obesity-like microenvironment in periprostatic fat

期刊

ENDOCRINE CONNECTIONS
卷 8, 期 5, 页码 547-558

出版社

BIOSCIENTIFICA LTD
DOI: 10.1530/EC-19-0029

关键词

prostate; cancer; obesity; adipose tissue; transcriptomics; transcriptomic econvolution

资金

  1. David Mayor PhD Scholarship from the Prostate Cancer Research Foundation
  2. Postgraduate Medical Research Scholarship from the Prostate Cancer Research Fund
  3. Australian Commonwealth Government
  4. University of Melbourne
  5. David Bickart Clinician Research Fellowship from the Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne
  6. Movember - Distinguished Gentleman's Ride Clinician Scientist Award through Prostate Cancer Foundation of Australia's Research Programme
  7. Victorian Cancer Agency Early Career Seed Grant [ECSG14010]

向作者/读者索取更多资源

Prostate cancer is a leading cause of morbidity and cancer-related death worldwide. Androgen deprivation therapy (ADT) is the cornerstone of management for advanced disease. The use of these therapies is associated with multiple side effects, including metabolic syndrome and truncal obesity. At the same time, obesity has been associated with both prostate cancer development and disease progression, linked to its effects on chronic inflammation at a tissue level. The connection between ADT, obesity, inflammation and prostate cancer progression is well established in clinical settings; however, an understanding of the changes in adipose tissue at the molecular level induced by castration therapies is missing. Here, we investigated the transcriptional changes in periprostatic fat tissue induced by profound ADT in a group of patients with high-risk tumours compared to a matching untreated cohort. We find that the deprivation of androgen is associated with a pro-inflammatory and obesity-like adipose tissue microenvironment. This study suggests that the beneficial effect of therapies based on androgen deprivation may be partially counteracted by metabolic and inflammatory side effects in the adipose tissue surrounding the prostate.

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