期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
卷 7, 期 8, 页码 2835-+出版社
ELSEVIER
DOI: 10.1016/j.jaip.2019.05.020
关键词
Chronic spontaneous urticaria; CD203c; Basophil activation test
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [15K09742, 16K19722]
- Grants-in-Aid for Scientific Research [15K09742, 16K19722] Funding Source: KAKEN
BACKGROUND: The insufficient effect of H1-antihistamine in some patients with chronic spontaneous urticaria (CSU) suggests that factors other than histamine are involved in the pathophysiology of CSU. Moreover, a central role for basophils in the pathophysiology of CSU has been hypothesized. However, few studies have focused on the relationship between basophil reactivity via Fc epsilon RI and clinical features in patients with CSU. OBJECTIVE: To assess basophil reactivity via Fc epsilon RI against anti-IgE and Fc epsilon RI stimulation in patients with CSU, and its association with disease activity in CSU. Fc epsilon RI expression and IgE binding on basophils from patients with CSU were also investigated. METHODS: We analyzed 38 patients with CSU, 8 patients with atopic dermatitis (AD), and 11 healthy controls (HCs). The surface CD203c expression with or without anti-IgE or Fc epsilon RI stimulation, and IgE and Fc epsilon RI (CRA1, CRA2) expression on blood basophils were evaluated. Patients with CSU were also evaluated and classified by disease activity and the above parameters were compared. RESULTS: The proportion of CD203c high basophils after anti-IgE or anti-Fc epsilon RI stimulation was lower in patients with CSU compared with HCs and patients with AD. It was lowest in the CSU group with severe disease. Basophils from patients with CSU had higher Fc epsilon RI (CRA1) expression, although it was not closely related to the severity of CSU. Subgroup analysis revealed that patients with CSU showing low responsiveness of basophils via Fc epsilon RI exhibited a short duration of disease but severe disease activity. CONCLUSIONS: Low reactivity of basophils via Fc epsilon RI is characteristic of patients with CSU. This attenuated reactivity is associated with severe clinical activity in patients with CSU (250 of 250). (C) 2019 American Academy of Allergy, Asthma & Immunology
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据