期刊
APPLIED SCIENCES-BASEL
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/app9071362
关键词
carbamazepine; cadmium; combined toxicity; biomarkers
类别
资金
- Natural Science Foundation of Jiangsu Province [BK20160989]
- National Key R&D Program of China [2017YFB0602500]
- Jiangsu Innovative and Entrepreneurial Doctor Program
- Nanjing Science and Technology Innovation Project for the Returned Overseas Scholars
In aquatic environments, organisms are exposed to mixtures of pollutants which may change the toxicity profile of each contaminant, compared to its toxicity alone. Carbamazepine (CBZ) and cadmium (Cd) are among the pollutants that co-occur in aquatic environments. To date, most research about their toxicity towards aquatic vertebrates is based on single exposure experiments. The present study aims to evaluate single and combined effects of CBZ and Cd on biomarkers in female Danio rerio (zebrafish) by exposing them to environmentally relevant concentrations of these two pollutants for ten days. Four kinds of biomarkers involved in antioxidant systems, energy metabolism, nervous system, and endocrine disruption, respectively, were studied. Our research results coincided with those of former studies in single exposure experiments. However, the combined exposure of CBZ and Cd exerted different responses from other studies in which these two contaminants were examined alone in zebrafish. The present study evidenced the need to conduct more coexposure studies to enhance the environmental relevance of these experimental results.
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