期刊
ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019
卷 6, 期 -, 页码 547-566出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-092818-015652
关键词
defective viral genomes; defective interfering particles; defective virus; viral interference; antiviral immunity
类别
资金
- NIAID NIH HHS [R21 AI127832, R01 AI137062, R01 AI083284, R01 AI134862] Funding Source: Medline
Defective viral genomes (DVGs) are generated during viral replication and are unable to carry out a full replication cycle unless coinfected with a full-length virus. DVGs are produced by many viruses, and their presence correlates with alterations in infection outcomes. Historically, DVGs were studied for their ability to interfere with standard virus replication as well as for their association with viral persistence. More recently, a critical role for DVGs in inducing the innate immune response during infection was appreciated. Here we review the role of DVGs of RNA viruses in shaping outcomes of experimental as well as natural infections and explore the mechanisms by which DVGs impact infection outcome.
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