期刊
ADVANCED SCIENCE
卷 6, 期 14, 页码 -出版社
WILEY
DOI: 10.1002/advs.201900530
关键词
metal-organic frameworks; photoacoustic imaging; photodynamic therapy; photosensitizer anion radical; superoxide anion radical
资金
- National Natural Science Foundation of China [21875008, 21475008, 51673023, 51773017]
- Special Foundation for State Major Research Program of China [2016YFC0106602, 2016YFC0106601]
- Fundamental Research Funds for the Central Universities [FRF-GF-17-B12, FRF-BD-17-016A]
Hypoxic tumor microenvironment is the bottleneck of the conventional photodynamic therapy (PDT) and significantly weakens the overall therapeutic efficiency. Herein, versatile metal-organic framework (MOF) nanosheets (DBBC-UiO) comprised of bacteriochlorin ligand and Hf-6(mu(3)-O)(4)(mu(3)-OH)(4) clusters to address this tricky issue are designed. The resulting DBBC-UiO enables numerous superoxide anion radical (O-2(-center dot)) generation via a type I mechanism with a 750 nm NIR-laser irradiation, part of which transforms to high toxic hydroxyl radical (OH center dot) and oxygen (O-2) through superoxide dismutase (SOD)-mediated catalytic reactions under severe hypoxic microenvironment (2% O-2), and the partial recycled O-2 enhances O-2(-center dot) generation. Owing to the synergistic radicals, it realizes advanced antitumor performance with 91% cell mortality against cancer cells in vitro, and highly efficient hypoxic solid tumor ablation in vivo. It also accomplishes photoacoustic imaging (PAI) for cancer diagnosis. This DBBC-UiO, taking advantage of superb penetration depth of the 750 nm laser and distinct antihypoxia activities, offers new opportunities for PDT against clinically hypoxic cancer.
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