期刊
ACS INFECTIOUS DISEASES
卷 5, 期 6, 页码 816-828出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsinfecdis.9b00019
关键词
oligopeptide; sideromycin; antibody-antibiotic conjugate; cell penetrating peptide; dendrimer; transferrin
资金
- National Institute of General Medical Sciences [GM119426]
- National Science Foundation [CHE1755698]
- Georgia Research Alliance based in Atlanta, Georgia
Innate and developed resistance mechanisms of bacteria to antibiotics are obstacles in the design of novel drugs. However, antibacterial prodrugs and conjugates have shown promise in circumventing resistance and tolerance mechanisms via directed delivery of antibiotics to the site of infection or to specific species or strains of bacteria. The selective targeting and increased permeability and accumulation of these prodrugs not only improves efficacy over unmodified drugs but also reduces off-target effects, toxicity, and development of resistance. Herein, we discuss some of these methods, including sideromycins, antibody-directed prodrugs, cell penetrating peptide conjugates, and codrugs.
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