期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 5, 期 5, 页码 2506-2518出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.9b00254
关键词
3D printing; poly(L-lactide)(PLLA); quercetin; osteogenic activity; dose-dependent
资金
- National Natural Science Foundation of China [31570981, 31771047]
- Science and Technology Planning Project of Guangdong, China [2017A010103042]
- Guangdong Provincial Natural Science Foundation of China [2016A030313086, 2018A030313052]
Quercetin (Qu), a bioflavonoid, has been reported to positively affect bone metabolism. For the first time, Qu with different concentrations was utilized to functionalize 3D-printed poly(L-lactide) (PLLA) scaffold with the aid of a polydopamine (PDA) layer through a convenient and effective way in this study. Results revealed that the coexistence of PDA and Qu can capacitate the 3D-printed PLLA scaffold to possess rougher surface, as well as better hydrophilicity and compressive properties. The resulting PDA-and Qu-modified PLLA scaffolds (Qu/PD-PLLA) can sustainably release Qu to some extent, which is more beneficial to the proliferation and attachment of MC3T3-E1 cells, upregulating ALP activity and calcium nodules as well as promoting the expression of related osteogenic genes and proteins. More significantly, such a positive impact of the Qu on the cell affinity and osteogenic activity played in a dose-dependent manner. This study revealed the potential of the 3D-printed Qu/PD-PLLA scaffolds with a certain amount of Qu as bone-repair materials.
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