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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Fully 2′-Deoxy-2′-Fluoro substituted nucleic acids induce RNA interference in mammalian cell culture
Richard A. Blidner et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2007)
Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA
Katarzyna Sipa et al.
RNA (2007)
Structural characterization and biological evaluation of small interfering RNAs containing cyclohexenyl nucleosides
Koen Nauwelaerts et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Molecular basis for target RNA recognition and cleavage by human RISC
Stefan Ludwig Ameres et al.
CELL (2007)
Oxepane nucleic acids: Synthesis, characterization, and properties of oligonucleotides bearing a seven-membered carbohydrate ring
David Sabatino et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
The human RNA kinase hClp1 is active on 3′ transfer RNA exons and short interfering RNAs
Stefan Weitzer et al.
NATURE (2007)
Nucleic acids with a six-membered carbohydrate mimic and RNA interference
Piet Herdewijn et al.
BLOOD CELLS MOLECULES AND DISEASES (2007)
Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo
Olaf R. Mook et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Inhibition of MDR1 expression with altritol-modified siRNAs
Michael Fisher et al.
NUCLEIC ACIDS RESEARCH (2007)
Solid-phase synthesis of modified RNAs containing amide-linked oligoribonucleosides at their 3 '-end and their application to siRNA
Reiko Iwase et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2007)
MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity
John J. Turner et al.
MOLECULAR BIOSYSTEMS (2007)
Illuminating the silence: understanding the structure and function of small RNAs
Tariq M. Rana
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
RNA interference tolerates 2 '-fluoro modifications at the Argonaute2 cleavage site
Pirkko Muhonen et al.
CHEMISTRY & BIODIVERSITY (2007)
Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting
Daniel De Paula et al.
RNA (2007)
Discovery and development of anticancer aptamers
Christopher R. Ireson et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification
Sujiet Puthenveetil et al.
NUCLEIC ACIDS RESEARCH (2006)
Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex
Carlos Frazao et al.
NATURE (2006)
Competition for RISC binding predicts in vitro potency of siRNA
Erich Koller et al.
NUCLEIC ACIDS RESEARCH (2006)
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
James O. McNamara et al.
NATURE BIOTECHNOLOGY (2006)
Position-specific chemical modification of siRNAs reduces off-target'' transcript silencing
Aimee L. Jackson et al.
RNA (2006)
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
M Lakadamyali et al.
CELL (2006)
Improving RNA interference in mammalian cells by 4′-thio-modified small interfering RNA (siRNA):: Effect on siRNA activity and nuclease stability when used in combination with 2′-O-alkyl modifications
P Dande et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Cleavage of the siRNA passenger strand during RISC assembly in human cells
PJF Leuschner et al.
EMBO REPORTS (2006)
Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
AD Judge et al.
MOLECULAR THERAPY (2006)
Target selectivity in mRNA silencing
N Aronin
GENE THERAPY (2006)
High potency silencing by single-stranded boranophosphate siRNA
Allison H. S. Hall et al.
NUCLEIC ACIDS RESEARCH (2006)
Improvements in siRNA properties mediated by 2 '-deoxy-2 '-fluoro-beta-D-arabinonucleic acid (FANA)
T Dowler et al.
NUCLEIC ACIDS RESEARCH (2006)
The roles of hydrogen bonding and sterics in RNA interference
Alvaro Somoza et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
C- versus N-terminally linked metittin-polyethylenimine conjugates: the site of linkage strongly influences activity of DNA potyplexes
S Boeckle et al.
JOURNAL OF GENE MEDICINE (2005)
Positional effect of chemical modifications on short interference RNA activity in mammalian cells
TP Prakash et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
RNA interference induced by siRNAs modified with 4′-thioribonucleosides in cultured mammalian cells
S Hoshika et al.
FEBS LETTERS (2005)
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
EW Song et al.
NATURE BIOTECHNOLOGY (2005)
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
N Parker et al.
ANALYTICAL BIOCHEMISTRY (2005)
Fully 2′-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA
CR Allerson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Cell-penetrating peptide conjugates of peptide nucleic acids (PNA) as inhibitors of HIV-1 Tat-dependent trans-activation in cells
JJ Turner et al.
NUCLEIC ACIDS RESEARCH (2005)
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
J Elmen et al.
NUCLEIC ACIDS RESEARCH (2005)
Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis
JS Wadia et al.
NATURE MEDICINE (2004)
siRNA relieves chronic neuropathic pain
G Dorn et al.
NUCLEIC ACIDS RESEARCH (2004)
Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells
A Muratovska et al.
FEBS LETTERS (2004)
Argonaute2 is the catalytic engine of mammalian RNAi
JD Liu et al.
SCIENCE (2004)
Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells
YL Chiu et al.
CHEMISTRY & BIOLOGY (2004)
RNA interference and chemically modified small interfering RNAs
M Manoharan
CURRENT OPINION IN CHEMICAL BIOLOGY (2004)
Kinetic analysis of the RNAi enzyme complex
B Haley et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
A protein sensor for siRNA asymmetry
Y Tomari et al.
SCIENCE (2004)
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
J Soutschek et al.
NATURE (2004)
Membrane destabilization by ricin
J Sun et al.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2004)
RNA interference using boranophosphate siRNAs: structure-activity relationships
AHS Hall et al.
NUCLEIC ACIDS RESEARCH (2004)
Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells
C Lorenz et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
JB Ma et al.
NATURE (2004)
The RNA-induced silencing complex is a Mg2+-dependent endonuclease
DS Schwarz et al.
CURRENT BIOLOGY (2004)
Liposomes modified with cyclic RGD peptide for tumor targeting
PK Dubey et al.
JOURNAL OF DRUG TARGETING (2004)
Functional siRNAs and rniRNAs exhibit strand bias
A Khvorova et al.
CELL (2003)
Antennapedia and HIV transactivator of transcription (TAT) protein transduction domains promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans
S Console et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Transport of dsRNA into cells by the transmembrane protein SID-1
EH Feinberg et al.
SCIENCE (2003)
siRNA function in RNAi: A chemical modification analysis
YL Chiu et al.
RNA (2003)
RNA interference in mammalian cells by chemically-modified RNA
DA Braasch et al.
BIOCHEMISTRY (2003)
Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells
F Czauderna et al.
NUCLEIC ACIDS RESEARCH (2003)
Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing
J Harborth et al.
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT (2003)
Tolerance for mutations and chemical modifications in a siRNA
M Amarzguioui et al.
NUCLEIC ACIDS RESEARCH (2003)
Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide
SP Henry et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2002)
Hybrid tetanus toxin C fragment-diphtheria toxin translocation domain allows specific gene transfer into PC12 cells
S Barati et al.
EXPERIMENTAL NEUROLOGY (2002)
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
SM Elbashir et al.
EMBO JOURNAL (2001)
Role for a bidentate ribonuclease in the initiation step of RNA interference
E Bernstein et al.
NATURE (2001)
Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity
J Wang et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2001)
Properties of arabinonucleic acids (ANA & 20 ' F-ANA): Implications for the design of antisense therapeutics that invoke RNase H cleavage of RNA
MJ Damha et al.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2001)
Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference
S Parrish et al.
MOLECULAR CELL (2000)
The Antennapedia peptide penetratin translocates across lipid bilayers -: the first direct observation
PEG Thorén et al.
FEBS LETTERS (2000)
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