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USP7 inhibitors, downregulating CCDC6, sensitize lung neuroendocrine cancer cells to PARP-inhibitor drugs
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USP7 is a SUMO deubiquitinase essential for DNA replication
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Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway
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USP7 controls Chk1 protein stability by direct deubiquitination
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CELL CYCLE (2014)
Ubiquitin-specific Protease 7 Regulates Nucleotide Excision Repair through Deubiquitinating XPC Protein and Preventing XPC Protein from Undergoing Ultraviolet Light-induced and VCP/p97 Protein-regulated Proteolysis
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The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of β-Catenin
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BCR-ABL disrupts PTEN nuclear-cytoplasmic shuttling through phosphorylation-dependent activation of HAUSP
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ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CH K1
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Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity
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Notch Simultaneously Orchestrates Multiple Helper T Cell Programs Independently of Cytokine Signals
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USP7 Regulates the Stability and Function of HLTF Through Deubiquitination
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Mechanism of USP7/HAUSP Activation by Its C-Terminal Ubiquitin-like Domain and Allosteric Regulation by GMP-Synthetase
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Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein
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C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site
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Degradation of MDM2 by the Interaction between Berberine and DAXX Leads to Potent Apoptosis in MDM2-Overexpressing Cancer Cells
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USP7 counteracts SCFβTrCP-but not APCCdh1-mediated proteolysis of Claspin
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The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network
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Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization
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Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity
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Ubiquitination regulates PTEN nuclear import and tumor suppression
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FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
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Critical role for Daxx in regulating Mdm2
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The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways
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Molecular recognition of p53 and MDM2 by USP7/HAUSP
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Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1: Implications for EBV-mediated immortalization
V Saridakis et al.
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Skp2 inhibits FOX01 in tumor suppression through ubiquitin-mediated degradation
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A dynamic role of HAUSP in the p53-Mdm2 pathway
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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
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Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
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MN Holowaty et al.
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PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms
DJ Freeman et al.
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Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
M Hu et al.
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