4.7 Review

USP7: Novel Drug Target in Cancer Therapy

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USP7 small-molecule inhibitors interfere with ubiquitin binding

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USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein

Amjad Ali et al.

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USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth

Tao An et al.

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USP7 is essential for maintaining Rad18 stability and DNA damage tolerance

A. Zlatanou et al.

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Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7

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Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis

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HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma

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USP7 is a SUMO deubiquitinase essential for DNA replication

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USP7 controls Chk1 protein stability by direct deubiquitination

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A Degrading View of Regulatory T Cells

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IMMUNITY (2013)

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Ubiquitination-Deubiquitination by the TRIM27-USP7 Complex Regulates Tumor Necrosis Factor Alpha-Induced Apoptosis

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Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription

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Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

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USP7 Regulates the Stability and Function of HLTF Through Deubiquitination

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Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein

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C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site

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USP7 counteracts SCFβTrCP-but not APCCdh1-mediated proteolysis of Claspin

Helene Faustrup et al.

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Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

Frederic Colland et al.

MOLECULAR CANCER THERAPEUTICS (2009)

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An additional role for SUMO in ubiquitin-mediated proteolysis

Marie-Claude Geoffroy et al.

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PML NBs (ND10) and Daxx: from nuclear structure to protein function

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The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

Min Sup Song et al.

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Mdm2 Induces Mono-Ubiquitination of FOXO4

Arjan B. Brenkman et al.

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High incidence of ubiquitin-like domains in human ubiquitin-specific proteases

Xiao Zhu et al.

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PTEN, more than the AKT pathway

Carmen Blanco-Aparicio et al.

CARCINOGENESIS (2007)

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Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity

Young Mi Oh et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

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Ubiquitination regulates PTEN nuclear import and tumor suppression

Lloyd C. Trotman et al.

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Stressing the role of FoxO proteins in lifespan and disease

Armando van der Horst et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

Armando van der Horst et al.

NATURE CELL BIOLOGY (2006)

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Critical role for Daxx in regulating Mdm2

Jun Tang et al.

NATURE CELL BIOLOGY (2006)

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Molecular recognition of p53 and MDM2 by USP7/HAUSP

Y Sheng et al.

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A genomic and functional inventory of deubiquitinating enzymes

SMB Nijman et al.

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Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells

E Bettelli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Skp2 inhibits FOX01 in tumor suppression through ubiquitin-mediated degradation

H Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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A dynamic role of HAUSP in the p53-Mdm2 pathway

MY Li et al.

MOLECULAR CELL (2004)

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

LT Vassilev et al.

SCIENCE (2004)

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Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1

YJ Shi et al.