期刊
CANCER MEDICINE
卷 8, 期 6, 页码 3012-3016出版社
WILEY
DOI: 10.1002/cam4.2168
关键词
checkpoint blockade; classic Hodgkin lymphoma; immune escape; multiplex immunohistochemistry; resistance; tumor microenvironment
类别
资金
- Centro di Riferimento Oncologico di Aviano (CRO) IRCCS
- Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano
Immune checkpoint-blocking antibodies have therapeutic activity against relapsed or progressive classic Hodgkin lymphoma (cHL), but Hodgkin Reed-Sternberg cells can develop resistance to this therapy via multiple mechanisms. To improve the efficacy of immune checkpoint blockade, we need a more precise understanding of the immune escape mechanisms active in individual cHL patients, and this requires a detailed characterization of immune cell populations in the tumor microenvironment. These cell-cell interactions can now be studied by multiplex immunohistochemistry coupled to digital image analysis. This method should allow the identification of actionable target molecules mediating resistance to immune checkpoint inhibitors in individual cHL patients, thereby favoring the implementation of personalized therapies.
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