期刊
MOBILE DNA
卷 10, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13100-019-0157-4
关键词
Endogenous retroviruses; Long terminal repeats; Long interspersed elements; Short interspersed elements; Germ line mutation; Inbred mice; Insertional mutagenesis; Transcriptional interference
资金
- Natural Sciences and Engineering Council of Canada - NIH [R21AG055387, R01AG057597]
- Brown Foundation
Transposable element (TE) insertions are responsible for a significant fraction of spontaneous germ line mutations reported in inbred mouse strains. This major contribution of TEs to the mutational landscape in mouse contrasts with the situation in human, where their relative contribution as germ line insertional mutagens is much lower. In this focussed review, we provide comprehensive lists of TE-induced mouse mutations, discuss the different TE types involved in these insertional mutations and elaborate on particularly interesting cases. We also discuss differences and similarities between the mutational role of TEs in mice and humans.
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