期刊
MEDICAL SCIENCE MONITOR
卷 25, 期 -, 页码 2609-2622出版社
INT SCIENTIFIC INFORMATION, INC
DOI: 10.12659/MSM.913471
关键词
Genes, Neoplasm; Genes, rRNA; Genes, vif; Uterine Cervical Neoplasms
资金
- National Natural Sciences Foundation of China [81673848, 81603520]
- Natural Sciences Foundation of Guangdong Province [2016A030310084, 2017A030313658]
- Science and Technical Plan of Guangzhou, Guangdong, China [201804010213, 201707010100]
- Administration of Traditional Medicine of Guangdong Province [20161063, 20181068]
- Fundamental Research Funds for the Central Universities [21616315]
- Medical Scientific Research Foundation of Guangdong Province [2016111221315850]
Background: More and more recent studies have clearly shown that long non-coding RNA (lncRNA) should be considered as a fundamental part of the ceRNA network, mainly because lncRNA can act as miRNA sponges to regulate the protein-coding gene expression. Nevertheless, it is still not clear how lncRNA-mediated ceRNAs function in cervical squamous cell carcinoma (CESC). Moreover, information about the ceRNA regulatory mechanism is also remarkably limited; thus, prediction of CESC prognosis using ceRNA-related information remains challenging. Material/Methods: We collected 306 RNA (lncRNA, miRNA, and mRNA) expression profile datasets obtained from cervical squamous cancer tissues plus 3 more from adjacent cervical tissues via the TCGA database. Subsequently, we constructed a lncRNAs-miRNAs-mRNAs CESC ceRNA network, and Gene Ontology (GO) analysis was carried out. Results: We identified a total of 30 DElncRNAs, 70 DEmiRNAs, and 1089 DEmRNAs in CESC. Subsequently, to reveal the expression patterns of dysregulated genes, weighted gene co-expression network analysis was carried out, resulting in 3 co-expression modules with significantly related clinical properties. The constructed aberrant lncRNAs-miRNAs-mRNAs CESC ceRNA network was composed of 17 DEmiRNAs, 5 DElncRNAs, and 7 DEmRNAs. Moreover, the survival analysis was performed for DElncRNAs, DEmiRNAs, and DEmRNAs. Conclusions: The present study shows the involvement of the lncRNA-related ceRNA network in the pathogenesis of CESC. We believe the newly generated ceRNA network will provide more insights into the lncRNA-mediated ceRNA regulatory mechanisms.
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