4.6 Article

Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions

期刊

FRONTIERS IN MICROBIOLOGY
卷 10, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2019.01013

关键词

fungi; simulated mars conditions; proteome; metabolome; Chernobyl; international space station; extremophiles

资金

  1. JPL Internal Development Program
  2. 2012 Space Biology [NNH12ZTT001N, 19-12829-26, NNN13D111T]
  3. JPL [1574847]
  4. NIH, National Cancer Institute Grant [P30 CA33572]

向作者/读者索取更多资源

Filamentous fungi have been associated with extreme habitats, including nuclear power plant accident sites and the International Space Station (ISS). Due to their immense adaptation and phenotypic plasticity capacities, fungi may thrive in what seems like uninhabitable niches. This study is the first report of fungal survival after exposure of monolayers of conidia to simulated Mars conditions (SMC). Conidia of several Chernobyl nuclear accident-associated and ISS-isolated strains were tested for UV-C and SMC sensitivity, which resulted in strain-dependent survival. Strains surviving exposure to SMC for 30 min, ISSFT-021-30 and IMV 00236-30, were further characterized for proteomic, and metabolomic changes. Differential expression of proteins involved in ribosome biogenesis, translation, and carbohydrate metabolic processes was observed. No significant metabolome alterations were revealed. Lastly, ISSFT-021-30 conidia re-exposed to UV-C exhibited enhanced UV-C resistance when compared to the conidia of unexposed ISSFT-021.

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