期刊
ELIFE
卷 8, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.44006
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资金
- Agence Nationale de la Recherche
- Human Frontier Science Program CDA
- H2020 European Research Council ERC CoG
- Seventh Framework Programme Marie Curie CiG
- Fondation pour l'Audition
- Ecole Doctorale Frontieres du Vivant (FdV) - Programme Bettencourt
- Paris-Saclay University
- Ecole des Neurosciences de Paris
Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner. In dark conditions, auditory cortex inputs lead to suppression of the V1 population. However, when sound input coincides with a visual stimulus, visual responses are boosted in V1, most strongly after loud sound onsets. Thus, a dynamic, asymmetric circuit connecting AC and V1 contributes to the encoding of visual events that are coincident with sounds.
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