期刊
ELIFE
卷 8, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.42256
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资金
- European Commission [656161]
- Japan Society for the Promotion of Science [18H06094]
- Yamaha Yamaha Sports Challenge Fellowship
- Fukuhara Fund for Applied Psychoeducation Research
- SENSHIN Medical Research Foundation
- Wellcome Trust [100227]
- Japan Science and Technology Agency [JPMJCR1304]
- Marie Curie Actions (MSCA) [656161] Funding Source: Marie Curie Actions (MSCA)
- Grants-in-Aid for Scientific Research [18H06094] Funding Source: KAKEN
How long neural information is stored in a local brain area reflects functions of that region and is often estimated by the magnitude of the autocorrelation of intrinsic neural signals in the area. Here, we investigated such intrinsic neural timescales in high-functioning adults with autism and examined whether local brain dynamics reflected their atypical behaviours. By analysing resting-state fMRI data, we identified shorter neural timescales in the sensory/visual cortices and a longer timescale in the right caudate in autism. The shorter intrinsic timescales in the sensory/visual areas were correlated with the severity of autism, whereas the longer timescale in the caudate was associated with cognitive rigidity. These observations were confirmed from neurodevelopmental perspectives and replicated in two independent cross-sectional datasets. Moreover, the intrinsic timescale was correlated with local grey matter volume. This study shows that functional and structural atypicality in local brain areas is linked to higher-order cognitive symptoms in autism.
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