期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 8, 期 7, 页码 1097-1101出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201900190
关键词
C-H activation; chemodivergence; pyridones; rhodium; synthetic methods
资金
- JSPS KAKENHI [JP 15H05485, 18K19078, JP 17H06092]
A solvent-controlled rhodium-catalyzed C6-selective alkenylation and alkylation of 2-pyridones with acrylates via a pyridine-directed C-H cleavage was developed. Using DMF as solvent, the C-H alkenylation with acrylates selectively occurs to deliver the corresponding C6-alkenylated 2-pyridones in good yields. On the other hand, the C6-alkylated products are predominantly formed in a more polar and protic solvent, HFIP. Thus, a single set of starting substrates can be divergently transformed to C6-functionalized 2-pyridones, which are of potent interest in medicinal and pharmaceutical chemistry.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据