期刊
ANDROLOGY
卷 7, 期 5, 页码 631-643出版社
WILEY
DOI: 10.1111/andr.12632
关键词
epididymal immunology; luminal acidification; male fertility; post-testicular regulation; tight junctions
类别
资金
- NICHD NIH HHS [R01 HD040793, R01 HD069623] Funding Source: Medline
- NIDDK NIH HHS [R01 DK097124] Funding Source: Medline
- Lalor Foundation Fellowship Funding Source: Medline
Epithelial cells line the lumen of tubular organs and are key players in their respective functions. They establish a unique luminal environment by providing a protective barrier and by performing vectorial transport of ions, nutrients, solutes, proteins, and water. Complex intercellular communication networks, specific for each organ, ensure their interaction with adjacent epithelial and non-epithelial cells, allowing them to respond to and modulate their immediate environment. In the epididymis, several epithelial cell types work in a concerted manner to establish a luminal acidic milieu that is essential for the post-testicular maturation and storage of spermatozoa. The epididymis also prevents autoimmune responses against auto-antigenic spermatozoa, while ensuring protection against ascending and blood pathogens. This is achieved by a network of immune cells that are in close contact and interact with epithelial cells. This review highlights the coordinated interactions between spermatozoa, basal cells, principal cells, narrow cells, clear cells, and immune cells that contribute to the maturation, protection, selection, and storage of spermatozoa in the lumen of the epididymis.
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