期刊
TOXINS
卷 11, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/toxins11050277
关键词
Fusarium; NRPS; secondary metabolites; Mycotoxins; ABC-transporter; peptidase
资金
- NovoNordisk Foundation [NNF15OC0016186]
- Obel Foundation
- Carlsberg Foundation
- Austrian Science Fund FWF [F-3703, M2149-B22]
- NFB-NO Forschung und Bildung [SC16-026]
- SparNord Foundation
Fungal non-ribosomal peptide synthetase (NRPS) clusters are spread across the chromosomes, where several modifying enzyme-encoding genes typically flank one NRPS. However, a recent study showed that the octapeptide fusaoctaxin A is tandemly synthesized by two NRPSs in Fusarium graminearum. Here, we illuminate parts of the biosynthetic route of fusaoctaxin A, which is cleaved into the tripeptide fusatrixin A and the pentapeptide fusapentaxin A during transport by a cluster-specific ABC transporter with peptidase activity. Further, we deleted the histone H3K27 methyltransferase kmt6, which induced the production of fusaoctaxin A.
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