期刊
BMJ OPEN
卷 9, 期 5, 页码 -出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/bmjopen-2018-026276
关键词
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资金
- University of Western Australia
- Curtin University
- Telethon Kids Institute
- Women and Infants Research Foundation
- Edith Cowan University
- Murdoch University
- University of Notre Dame Australia
- Raine Medical Research Foundation
- National Health and Medical Research Council of Australia [880441, 930745, 963209, 211912, 003209, 32300, 403981, 353514, 458623, 403968, 572613, 1084947, 1080492]
- King Edward Memorial Hospital Research Foundation
- Glaxo Wellcome
- Asthma Foundation of Western Australia
- Healthway [6006, 14123]
- Telstra Foundation
- Cardiovascular Lipid Pfizer Grant
- Australian Arthritis Foundation
- Stanley Trust (UK)
- Ada Bartholomew Medical Research Trust
- Gastroenterology Society of Australia
- Fremantle Hospital Medical Research Foundation
- Rotary Health Research
- Canadian Institutes of Health Research
- National Heart Foundation
- Channel 7 Telethon Trust
- Princess Margaret Hospital Foundation
- Dairy Health and Nutrition Consortium
- Danish Council for Strategic Studies
- Smarttots
- Asthma Foundation
- Western Australia Department of Health Future Health Fund
- Western Australia Department of Health Targeted Research Fund
- National Health and Medical Research Council of Australia [1080492, 1084947] Funding Source: NHMRC
Purpose The purpose of the Raine Study is to improve human health and well-being by studying the life-course of a cohort of Western Australians, based on a life-course conceptual framework that considers interactions between genetics, phenotypes, behaviours, the environment and developmental and social outcomes. Participants Between May 1989 and November 1991, 2900 pregnant women were enrolled in the Raine Study in Perth, Western Australia. In total, 2730 women gave birth to 2868 children (Generation 2) between August 1989 and April 1992. The mothers and fathers of Generation 2 are referred to as Generation 1 of the Raine Study. In the most recent Generation 1 follow-up, 636 mothers and 462 fathers participated. Findings to date Until the 26-year follow-up of Generation 1 the focus of research within the Raine Study was on outcomes in Generation 2, with information on the parents mainly being used to examine its influence on their children's outcomes. For example, recent findings showed that several characteristics of mothers, such as obesity, early mid-gestational weight gain and socioeconomic status were associated with non-alcoholic fatty liver disease, adiposity and cardiometabolic characteristics in offspring. Other findings showed that parents with back pain were more likely to have offspring who experienced back pain. Also, non-linear and dynamic relationships were found between maternal working hours and offspring overweight or obesity. Future plans The Raine Study will continue to provide access to its dense longitudinal genetic, phenotypic, behavioural, environmental, developmental and social data to undertake studies with the ultimate goal of improving human health and well-being. Analyses of data from the recent Generation 1 year 26 follow-up are underway.
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