4.6 Article

Aetiology and risks factors associated with the fatal outcomes of childhood pneumonia among hospitalised children in the Philippines from 2008 to 2016: a case series study

期刊

BMJ OPEN
卷 9, 期 3, 页码 -

出版社

BMJ PUBLISHING GROUP
DOI: 10.1136/bmjopen-2018-026895

关键词

-

资金

  1. Japan Initiative for Global Research Network on Infectious Diseases from the Japan Agency for Medical Research and Development (AMED) [JP18fm108013]
  2. Science and Technology Research Partnership for Sustainable Development from AMED
  3. Japan International Cooperation Agency [JP16jm0110001]

向作者/读者索取更多资源

Objective Pneumonia remains the leading cause of hospitalisations and deaths among children aged < 5 years. Diverse respiratory pathogens cause acute respiratory infections, including pneumonia. Here, we analysed viral and bacterial pathogens and risk factors associated with death of hospitalised children. Design A 9-year case series study. Setting Two secondary-care hospitals, one tertiary-care hospital and one research centre in the Philippines. Participants 5054 children aged < 5 years hospitalised with severe pneumonia. Methods Nasopharyngeal swabs for virus identification, and venous blood samples for bacterial culture were collected. Demographic, clinical data and laboratory findings were collected at admission time. Logistic regression analyses were performed to identify the factors associated with death. Results Of the enrolled patients, 57% (2876/5054) were males. The case fatality rate was 4.7% (238/5054), showing a decreasing trend during the study period (p< 0.001). 55.0% of the patients who died were either moderately or severely underweight. Viruses were detected in 61.0% of the patients, with respiratory syncytial virus (27.0%) and rhinovirus (23.0%) being the most commonly detected viruses. In children aged 2-59 months, the risk factors significantly associated with death included age of 2-5 months, sensorial changes, severe malnutrition, grunting, central cyanosis, decreased breath sounds, tachypnoea, fever (= 38.5 degrees C), saturation of peripheral oxygen < 90%, infiltration, consolidation and pleural effusion on chest radiograph. Among the pathogens, adenovirus type 7, seasonal influenza A (H1N1) and positive blood culture for bacteria were significantly associated with death. Similar patterns were observed between the death cases and the aforementioned factors in children aged < 2 months. Conclusion Malnutrition was the most common factor associated with death and addressing this issue may decrease the case fatality rate. In addition, chest radiographic examination and oxygen saturation measurement should be promoted in all hospitalised patients with pneumonia as well as bacteria detection to identify patients who are at risk of death.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据