期刊
ADVANCED HEALTHCARE MATERIALS
卷 8, 期 11, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201900036
关键词
atherosclerosis; nanoagents; stimuli-responsiveness
资金
- National Natural Science Foundation of China [11572064, 51603023]
- Fundamental Research Funds for the National Key RD Project [2016YFC1102305]
- Fundamental Research Funds for Central Universities [2018CDHB1B08, 2018CDXYSW0023, 106112016CDJXY230002, 106112018CDPTCG0001-10]
- Chongqing Research Program of Basic Research and Frontier Technology [cstc2017jcyjAX0186]
Atherosclerosis is the root of approximately one-third of global mortalities. Nanotechnology exhibits splendid prospects to combat atherosclerosis at the molecular level by engineering smart nanoagents with versatile functionalizations. Significant advances in nanoengineering enable nanoagents to autonomously navigate in the bloodstream, escape from biological barriers, and assemble with their nanocohort at the targeted lesion. The assembly of nanoagents with endogenous and exogenous stimuli breaks down their shells, facilitates intracellular delivery, releases their cargo to kill the corrupt cells, and gives imaging reports. All these improvements pave the way toward personalized medicine for atherosclerosis. This review systematically summarizes the recent advances in stimuli-responsive nanoagents for atherosclerosis management and its progress in clinical trials.
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