期刊
ADVANCED HEALTHCARE MATERIALS
卷 8, 期 11, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201801374
关键词
biomaterials; coiled-coils; engineered proteins; functional materials; recombinant protein
资金
- NSF-DMREF [DMR 1728858]
- NSF-MRSEC Program [DMR 1420073]
- NSF BMAT [DMR 1505214]
- ARO [W911NF-15-1-0304]
- NYU Shiffrin-Myers Breast Cancer Discovery Fund
- NYU CTSA from the National Center for Advancing Translational Sciences, National Institutes of Health [UL1 TR000038]
Proteins are versatile macromolecules that can perform a variety of functions. In the past three decades, they have been commonly used as building blocks to generate a range of biomaterials. Owing to their flexibility, proteins can either be used alone or in combination with other functional molecules. Advances in synthetic and chemical biology have enabled new protein fusions as well as the integration of new functional groups leading to biomaterials with emergent properties. This review discusses protein-engineered materials from the perspectives of domain-based designs as well as physical and chemical approaches for crosslinked materials, with special emphasis on the creation of hydrogels. Engineered proteins that organize or template metal ions, bear noncanonical amino acids (NCAAs), and their potential applications, are also reviewed.
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