期刊
ACS SYNTHETIC BIOLOGY
卷 8, 期 6, 页码 1241-1248出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssynbio.9b00100
关键词
synthetic biology; DNA storage; information storage; nested architecture; file access; DNA sequencing
资金
- National Science Foundation [CNS-1650148]
- North Carolina State University Research and Innovation Seed Funding Award [2018-2509]
- North Carolina Biotechnology Center Flash Grant
- Department of Education Graduate Assistance in Areas of Need Fellowship
- North Carolina State University Research Experience for Undergraduates, Provost's Professional Experience Programs
- NCSU startup funds
The extreme density of DNA presents a compelling advantage over current storage media; however, to reach practical capacities, new systems for organizing and accessing information are needed. Here, we use chemical handles to selectively extract unique files from a complex database of DNA mimicking 5 TB of data and design and implement a nested file address system that increases the theoretical maximum capacity of DNA storage systems by five orders of magnitude. These advancements enable the development and future scaling of DNA-based data storage systems with modem capacities and file access capabilities.
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