期刊
ACS MACRO LETTERS
卷 8, 期 4, 页码 473-478出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.9b00016
关键词
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资金
- Mexican National Council for Science and Technology (CONACyT)
- Karlsruhe House of Young Scientist (KHYS)
- NIH-NCI [1R01CA220468-01]
- NIH [U01-N5090451]
- National Science Foundation
- Koch Institute Support (core) Grant from the National Cancer Institute [P30-CA14051]
- German Federal Ministry of Education and Research (BMBF) through the Molecular Interaction Engineering: From Nature's Toolbox to Hybrid Technical Systems program [031A095B]
The synthesis of functional poly(2-alkyl-2-oxazoline) (PAOx) copolymers with complex nanoarchitectures using a graft-through ring-opening metathesis polymerization (ROMP) approach is described. First, well-defined norbornene-terminated poly(2-ethyl-2-oxazoline) (PEtOx) macromonomers (MM) were prepared by cationic ring-opening polymerization. ROMP of these MMs produced bottlebrush copolymers with PEtOx side chains. In addition, PEtOx-based branched MMs bearing a terminal alkyne group were prepared and conjugated to an azide-containing bis-spirocyclohexyl nitroxide via Cu-catalyzed azide-alkyne cycloaddition (CuAAC). ROMP of this branched MM, followed by in situ cross-linking, provided PEtOx-based brush-arm star polymers (BASPs) with nitroxide radicals localized at the core-shell interface. These PEtOx-based nitroxide-containing BASPs displayed relaxivity values on par with state-of-the-art polyethylene glycol (PEG)-based nitroxide materials, making them promising as organic radical contrast agents for metal-free magnetic resonance imaging (MRI).
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