期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 61, 期 1, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01106-16
关键词
In vitro susceptibility; triazole derivatives; Candida species
资金
- School of Medicine, Mazandaran University of Medical Sciences (Sari, Iran) [2321]
The in vitro activities of two novel azole compounds (aryl-1,2,4-triazol-3- ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical Candida isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates) Candida isolates.
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