期刊
CURRENT PSYCHIATRY REPORTS
卷 21, 期 6, 页码 -出版社
SPRINGER
DOI: 10.1007/s11920-019-1026-z
关键词
Cannabidiol; Consolidation; Endocannabinoid; Extinction; Fear conditioning; Reconsolidation
类别
资金
- Biotechnology and Biological Sciences Research Council [BB/M008770/1]
- BBSRC [2285560] Funding Source: UKRI
Purpose of ReviewAnxiety- and trauma-related disorders are prevalent and debilitating mental illnesses associated with a significant socioeconomic burden. Current treatment approaches often have inadequate therapeutic responses, leading to symptom relapse. Here we review recent preclinical and clinical findings on the potential of cannabinoids as novel therapeutics for regulating fear and anxiety.Recent FindingsEvidence from preclinical studies has shown that the non-psychotropic phytocannabinoid cannabidiol and the endocannabinoid anandamide have acute anxiolytic effects and also regulate learned fear by dampening its expression, enhancing its extinction and disrupting its reconsolidation. The findings from the relevant clinical literature are still very preliminary but are nonetheless encouraging.SummaryBased on this preclinical evidence, larger-scale placebo-controlled clinical studies are warranted to investigate the effects of cannabidiol in particular as an adjunct to psychological therapy or medication to determine its potential utility for treating anxiety-related disorders in the future.
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