期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 60, 期 9, 页码 5595-5599出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00389-16
关键词
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资金
- Merck Investigator Studies Program [39543]
- Oesterreichische Nationalbank (OeNB) [15346]
Low posaconazole plasma concentrations (PPCs) have been associated with breakthrough invasive fungal infections. We assessed the correlation between pre-steady-state PPCs (obtained between days 3 and 5) and PPCs obtained during steady state in 48 patients with underlying hematological malignancies receiving posaconazole oral-solution prophylaxis. Pre-steady-state PPCs correlated significantly with PPCs obtained at steady state (Spearman r = 0.754; P < 0.001). Receiver operating characteristic (ROC) curve analysis of pre-steady-state PPCs revealed an area under the curve (AUC) of 0.884 (95% confidence interval [CI], 0.790 to 0.977) for predicting satisfactory PPCs at steady state.
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