期刊
BMC PREGNANCY AND CHILDBIRTH
卷 19, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12884-019-2291-x
关键词
Assisted reproductive technology; Preeclampsia; Infertility; Meta-analysis; Systematic review
资金
- National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care, North West Coast (NIHR CLAHRC NWC)
BackgroundThe objective of this systematic review and meta-analyses was to assess the risk of preeclampsia among women who conceived with assisted reproductive technology (ART).MethodsWe searched the ISI Web of Knowledge, Medline/PubMed, Scopus, and Embase (from inception to May 2017) for English language articles using a list of key words. In addition, reference lists from identified studies and relevant review articles were also searched. Data extraction was performed by two authors, and the study quality was assessed using the Newcastle-Ottawa Scale. Random-effects model meta-analysis was applied to pool the relative risks (RR) across studies.ResultsA total of 48 studies (5 case-control studies and 43 cohort studies) were included in this meta-analysis. The Cochran Q test and I-2 statistics revealed substantial heterogeneity (Q=26,313.92, d.f. = 47, p<0.001 and I-2=99.8%). Meta-analysis showed a significant increase in preeclampsia in women who conceived by ART compared with those who conceived spontaneously (RR=1.71, 95% CI=1.11-2.62, p=0.015).ConclusionsThe findings of this systematic review indicate that the use of ART treatment is associated with a 1.71-fold increase in preeclampsia.
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