期刊
ONCOLOGY LETTERS
卷 18, 期 1, 页码 117-126出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2019.10293
关键词
human leukocyte antigen class I; beta 2-microglobulin antigen; non-small-cell lung cancer; immunohistochemistry
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [18591534]
- Grants-in-Aid for Scientific Research [18591534] Funding Source: KAKEN
The aim of this study was to clarify the association between expression of human leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival curves were compared using the log-rank test. In addition, multivariate analyses were performed using Cox's proportional hazard model. The cases were divided into 5 classes based on the expression of HLA class I heavy chain and beta 2-microglobulin. The overall survival rate for patients with tumors lacking HLA class I heavy chain (30 cases; 27.0%) was significantly decreased. The multivariate analysis demonstrated that the absence of HLA class I heavy chain was an independent predictor of poor prognosis. There was a trend towards an unfavorable prognosis for patients whose tumors did not express beta 2-microglobulin (57 cases; 51.4%). Downregulation of HLA class I heavy chain expression was significantly associated with the downregulation of beta 2-microglobulin. Cases lacking HLA class I heavy chain as well as beta 2-microglobulin expression (23 cases; 20.7%) had a statistically significant unfavorable prognosis compared with other cases. The present findings demonstrate that the lack of HLA class I heavy chain expression in tumor cells is an independent prognostic factor for poor NSCLC survival, and is likely to exert an important influence on immune surveillance in patients.
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