期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 60, 期 9, 页码 5592-5594出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00913-16
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资金
- Royal Liverpool
- Broadgreen University Hospitals NHS Trust
There is an urgent need for new antibiotics to treat multidrug-resistant Neisseria gonorrhoeae. In this report, the microbiology, in vivo pharmacokinetics, and efficacy of REDX05931, a representative novel tricyclic topoisomerase inhibitor, were evaluated. REDX05931 demonstrated high oral bioavailability in mice and reduced N. gonorrhoeae infection after a single dose in a mouse model of gonorrhea. These data support the potential of this series of small molecules as a new treatment for drug-resistant gonorrheal infections.
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