期刊
JOURNAL OF FUNCTIONAL FOODS
卷 55, 期 -, 页码 76-85出版社
ELSEVIER
DOI: 10.1016/j.jff.2019.02.019
关键词
5-Demethylnobiletin; Peanut protein; Pickering emulsion; In vitro digestion; Bioaccessibility; Transport
资金
- National Natural Science Foundation of China [21667018, 31660482]
- Planning Subject of The Twelfth Five-Year-Plan National Science and Technology for the Rural development of China [2013AA102203-05]
- Natural Science Foundation of Jiangxi Province of China [20171BBF60047]
- Key project for science and technology research of Jiangxi province in 2018 [5511]
5-demethylnobiletin (5DN) in aged citrus peel (chenpi) is a unique polymethoxyflavone that has been shown to exhibit superior anti-cancer effects, but its low water-solubility and poor oral bioavailability may limit its application as a potent nutraceutical. In this study, Se-enriched peanut protein nanoparticles-stabilized Pickering emulsions (PPEs) were used to encapsulate 5DN to enhance its bioaccessibility, cellular uptake and transport rate. The preparation of PPEs, and their digestion profiles in gastrointestinal tract, cell uptake and transport were investigated. Results showed that the bioaccessibility of 5DN was significantly higher within PPEs (18.3%) than in bulk oil (9.2%). Besides, PPEs-encapsulated 5DN has a greater apical-to-basolateral (AP-BL) transport rate (26.9 x 10(-6) cm s(-1)) than 5DN (21.7 x 10(-6) cm s(-1)). It was proved PPEs may promote the bioavailability of 5DN, and this type of delivery system may be useful for the application of 5DN and other crystalline nutraceuticals in functional foods and beverages.
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