期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 25, 期 17, 页码 2058-2070出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v25.i17.2058
关键词
Proton pump inhibitor; Gastric cancer; Drug resistance; Signal transducer and activator of transcription 3
资金
- Basic Science Research Program through the National Research Foundation of Korea [NRF-2016R1D1A1A02936964]
Proton pump inhibitors (PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicohacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggesting the need for comprehensive and confirmative studies are needed in the future. Meanwhile, several experimental studies have demonstrated the effects of PPIs in reducing chemoresistance in gastric cancer cells by modulating the acidic microenvironment, cancer sternness and signal transducer and activator of transcription 3 (STAT3) signaling pathway. The inhibitory effects of PPIs on STAT3 activity may overcome drug resistance and enhance the efficacy of conventional or targeted chemotherapeutic agents. Taken together, PPIs may play dual role in gastric carcinogenesis and treatment of gastric cancer.
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