期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 60, 期 5, 页码 3145-3147出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02216-15
关键词
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资金
- MCTI \ Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [55675/2009-2, 404455/2012-3]
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) [E-26/110.610/2012]
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) [16712]
Most antimalarial drugs target asexual parasites without reducing gametocyte formation or development. Drugs with dual roles, i.e., those that can target both asexual parasites and gametocytes, would improve the control of malaria. In the current study, MEFAS, a hybrid drug derived from mefloquine and artesunate that has been shown to be an active blood schizonticidal drug, was assessed to determine its ability to block the infectivity of Plasmodium falciparum gametocytes. MEFAS was 280 and 15 times more effective than mefloquine alone and artesunate alone, respectively.
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