期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 45, 期 7, 页码 1509-1536出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2018.12.015
关键词
Ultrasound; Neuromodulation; Brain stimulation; Non-invasive; Mechanisms; Safety
资金
- Engineering and Physical Sciences Research Council (EPSRC) [EP/F500394/1]
- Oxford Centre for Drug Delivery Devices (OXCD3) [EP/L024012/1]
- Medical Research Council Clinician Scientist Fellowship [MR/K010395/1]
- John Fell Fund [163/113]
- Wellcome Trust [105651/Z/14/Z]
- Wellcome Centre for Integrative Neuroimaging [203139/Z/16/Z]
- MRC [MR/K010395/1] Funding Source: UKRI
- Wellcome Trust [105651/Z/14/Z] Funding Source: Wellcome Trust
Ultrasonic neuromodulation is a rapidly growing field, in which low-intensity ultrasound (US) is delivered to nervous system tissue, resulting in transient modulation of neural activity. This review summarizes the findings in the central and peripheral nervous systems from mechanistic studies in cell culture to cognitive behavioral studies in humans. The mechanisms by which US mechanically interacts with neurons and could affect firing are presented. An in-depth safety assessment of current studies shows that parameters for the human studies fall within the safety envelope for US imaging. Challenges associated with accurately targeting US and monitoring the response are described. In conclusion, the literature supports the use of US as a safe, non-invasive brain stimulation modality with improved spatial localization and depth targeting compared with alternative methods. US neurostimulation has the potential to be used both as a scientific instrument to investigate brain function and as a therapeutic modality to modulate brain activity. (C) 2019 The Author(s). Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.
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