期刊
TRENDS IN MOLECULAR MEDICINE
卷 25, 期 6, 页码 494-515出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2019.04.006
关键词
-
资金
- Rubicon Grant from The Netherlands Organisation for Scientific Research
- Stem Cell Grant from BD Biosciences
- Empire State Stem Cell Fund through New York State Department of Health [DOH01-C30291GG-3450000]
- NIH [1R35HL135763]
- LLS Scholar Award
Aging leads to functional decline of the hematopoietic system, manifested by an increased incidence of hematological disease in the elderly. Deterioration of hematopoietic integrity with age originates in part from the degraded functionality of hematopoietic stem cells (HSCs). Here, we review recent findings identifying changes in metabolic programs and loss of epigenetic identity as major drivers of old HSC dysfunction and their role in promoting leukemia onset in the context of age-related clonal hematopoiesis (ARCH). We discuss how inflammatory and growth signals from the aged bone marrow (BM) microenvironment contribute to cell-intrinsic HSC aging phenotypes and favor leukemia development. Finally, we address how metabolic, epigenetic, and inflammatory pathways could be targeted to enhance old HSC fitness and prevent leukemic transformation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据